distal Renal Tubular Acidosis (dRTA)

dRTA can be either genetically inherited or acquired. The inherited form of dRTA, also known as primary dRTA, is most common among infants and children, while the acquired form is more common in adults. Acquired dRTA can be due to autoimmune disorders, rheumatoid arthritis, or to certain medications.

An estimated 30,000 patients in Europe and 20,000 patients in the United States suffer from dRTA, which was first described in the 1930s.

Mineral imbalances caused by dRTA can lead to kidney stones and hypokalemia, or decreased levels of potassium in the blood. Hypokalemia causes severe muscle weakness, shortness of breath and abnormal heart rhythm.

dRTA can cause digestive disorders, such as anorexia, vomiting, diarrhea, and constipation, and can also lead to hearing loss.

Because of the complications associated with traditional treatment, Advicenne has developed an innovative product in an oral pharmaceutical form, appropriate for children and adults, a global treatment which maintains a sustained-release of various agents along the entire intestinal tract over 12 hours for a twice-a-day administration, thus maximizing absorption of the agents, re-establishing homeostasis, and avoiding abdominal pain.